The Binding of Isaac Rebirth: Jacob and Esau / twins guide

Lead Esau, leaving Jacob in place is impossible. When moving to another room, the twins will always stand close to each other.. Hold CTRL to throw away key fobs and cards / pills (RT), standing still

IMPORTANT: If the character has two slots, then the items will swap when holding CTRL (RT).

Red indicators – Esau's figures. The speed of the characters is the same.
Rate of fire, the speed of the shot and the luck of Jacob is higher, than Esau, but Esau has higher range and damage. I recommend upgrading both characters, based on their performance. One character upgrade strategy is effective, however, the character thus loses its individuality and potential to be an analogue 20/20 on other characters.

Gemini can plant two bombs at the same time, while spending only one bomb. This not only allows you to simultaneously explode blue stones and find secret rooms, but also quickly kill the bosses first 4-5 floors, deal extra damage to late game bosses.

When entering a room, characters are close to each other, however, they are crooked. IMPORTANT: that character will stand in front, who entered the room.

When entering a room with opponents, bump into the door. It does not take much time, and it will become easier to control characters.

When clearing rooms, it is important to consider room generation: chasms and stones – not your friends at all.

Each item affects the character, who took / used it. Keep this in mind and do not use the Chariot card to clear rooms..

Jacob and Esau can take both items, which are given to choose. To do this, stand in front of the objects., bury yourself in the wall and run forward to objects. Therefore, I recommend not to miss the Downpoor / Dross and Mines / Ashpit floors.. This mechanic makes the angel more attractive., as he often has items to choose from.

Deal with the devil
Deal with the Devil will always be for red hearts as long as one of the characters has red hearts. If the character has one heart, then he can buy items for 2.

This section exists due to the misconception of many players.. Transforms from active items cannot be given to both characters. As soon as one of the characters picks up an active item, the game assigns this item to it and after that the item is registered as already picked up.